Leibniz-Institute for Molecular Pharmacology (FMP)
Research Infrastructure affiliation: EU-OPENSCREEN
Location: Berlin, Germany
Website address: http://www.leibniz-fmp.de
Local Access Officer: Dr. Franziska Ringleb (email@example.com)
The Leibniz-Institute for Molecular Pharmacology (FMP) is a basic research institute focusing on Molecular Pharmacology with the aim to identify novel bioactive molecules and to characterize their interactions with their biological targets in cells and/or organisms. Such bioactive compounds can be useful molecular tools for basic biomedical research and they may be developed further for the treatment, prevention, or diagnosis of disease. To this end, FMP researchers study key biological processes and corresponding diseases, such as, for example, cancer or neurodegeneration. Development and application of advanced technologies—ranging from screening technologies over NMR based methods to proteomics—is another focus of the institute.
The FMP conducts basic research in Molecular Pharmacology with a clear focus on the identification, characterization, and manipulation of novel biological targets for pharmacological interference. To this end, research at the FMP follows an interdisciplinary approach, combining structural biology, genetics, biochemistry, chemical biology, and bio-imaging to develop novel strategies to monitor and manipulate biological function. The FMP is divided into three research departments—namely 1) Molecular Physiology and Cell Biology, 2) Structural Biology, and 3) Chemical Biology.
The FMP Screening Unit focuses on bioprofiling of chemical compounds and systematic screening of large compound libraries or genome-wide RNAi libraries with state-of-the-art equipment like automated microscopes and microfluidic liquid handling systems. The mission of the platform is to enable access for academic projects to experiments in high-throughput format without the loss of any IP generated. The Screening Unit is also part of the Chemical Biology Platform at the FMP, which adds Medicinal Chemistry and Drug Design as potential follow-ups to the initial high-throughput screening. A detailed list of the available equipment can be found here.
The Cellular Imaging Facility offers advanced Imaging Super-resolution imaging and electron microscopy analysis with the following equipment.
Transnational Access users will have access to the FMP bioprofiling services for newly isolated natural products in order to determine basic biological properties using high-content microscopy assays. Expertise in the set-up of biochemical assays is provided. If the molecular structures of a compound and its corresponding target are available, in-silico molecular docking experiments can be supported.
The Cellular Imaging Facility offers advice with labelling of samples for STED and STORM, provides acces to gSTED and custom build dSTORM setups and helps with imaging and image analysis. Liposomes and protein samples can be screened for optimal cryo-conditions for subsequent single particle analysis and cryo EM structure determination.